BDBM639344 2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{3-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]-2-methylbenzene-1-sulfonyl}-S-alaninate hydrochloride::US20230391761, Reference 12

SMILES Cc1c(cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)OCCc1nccn1C)N1CC[C@H](O)C1=O

InChI Key InChIKey=JSZQNSABSYYEPQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 639344   

TargetCoagulation factor X(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 0.610nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetProthrombin(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 16nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCoagulation factor XI(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetSerine protease 1(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 2.00E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetPlasminogen(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.90E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetTissue-type plasminogen activator(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.10E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetKallikrein-1(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639344(2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.60E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent