BDBM640236 5-{6-[2-(7-Chloro-benzo[b]thiophen-5-yl)-ethylamino]-pyrimidin-4-yl}-3-ethoxy- thiophene-2-carboxylic acid::US11839613, Example 359

SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc(Cl)c3sccc3c2)ncn1

InChI Key InChIKey=GVBCXNNCRNDEBH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640236   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM640236(5-{6-[2-(7-Chloro-benzo[b]thiophen-5-yl)-ethylamin...)
Affinity DataIC50: 2nMAssay Description:The BT549 cells (NCI/No. 0507282) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent

TargetProstaglandin E2 receptor EP2 subtype(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM640236(5-{6-[2-(7-Chloro-benzo[b]thiophen-5-yl)-ethylamin...)
Affinity DataIC50: 61nMAssay Description:The SF295 cells (NCI/No. 0503170) are detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected in growing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2024
Entry Details
US Patent