BDBM642362 US20230406840, Example 36
SMILES FC(F)(F)C1(CC1)c1ccc2c(ccnc2c1)C(=O)NCC(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
InChI Key InChIKey=NJMHTAKVUZRTFZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 642362
Affinity DataIC50: 3.40nMAssay Description:Table 1A: Compounds were tested in a biochemical inhibition assay using hFAP enzyme at 0.24 nM FAC (Proteros, 38-760 (PR-0071)) and the substrate Ala...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Table 1A: Compounds were tested in a biochemical inhibition assay using human Fibroblast activation protein alpha (hFAP) enzyme at 2.4 μM FAC (P...More data for this Ligand-Target Pair
Affinity DataKd: 4.30nMAssay Description:Table 1B: Compounds were tested in a direct binding assay using 8K surface plasmon resonance biosensor (GE Healthcare) at 20° C. Immobilization of hF...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair