BDBM643755 (4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-methyl-8-(trifluoromethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 108

SMILES CCc1nnc2[C@H](C)N=C(c3c(F)cccc3F)c3c(Cl)c(ccc3-n12)C(F)(F)F

InChI Key InChIKey=PTBYJGHBJRYPAZ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 643755   

LigandPNGBDBM643755((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...)
Affinity DataKi:  2nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

LigandPNGBDBM643755((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...)
Affinity DataKi:  47nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

LigandPNGBDBM643755((4S)-7-chloro-6-(2,6-difluorophenyl)-1-ethyl-4-met...)
Affinity DataKi:  2.37E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent