BDBM644597 Preparation of 12,12,19-trimethyl-8-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2λ6-thia-3,9,11,19,24-pentaazatetracyclo[18.3.1.05,10.011,15]tetracosa-1(23),5,7,9,20(24),21-hexaene-2,2,4-trione ::US11866450, Compound 9

SMILES CN1CCCC2CCC(C)(C)N2c2nc(ccc2C(=O)NS(=O)(=O)c2cccc1n2)-n1ccc(OCCC2(CC2)C(F)(F)F)n1

InChI Key InChIKey=URRRUCZLZHRNNI-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 644597   

TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM644597(US11866450, Compound 9 | Preparation of 12,12,19-t...)
Affinity DataEC50: <1.00E+3nMAssay Description:Bath 1 Buffer consisted of 1 mM MgCl2, 160 mM NaCl, 4.5 mM KCl, 10 mM HEPES, 10 mM Glucose, 2 mM CaCl2).Chloride Free Buffer consisted of 1 mM Magnes...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2024
Entry Details
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