BDBM644605 Preparation of 6,6-dimethyl-10-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-16λ6-thia-2,7,9,15,21-pentaazatetracyclo[15.3.1.14,7.08,13]docosa-1(20),8,10,12,17(21),18-hexaene-14,16,16-trione ::US11866450, Compound 17

SMILES CC1(C)CC2CN1c1nc(ccc1C(=O)NS(=O)(=O)c1cccc(NC2)n1)-n1ccc(OCCC2(CC2)C(F)(F)F)n1

InChI Key InChIKey=CQZHZNFUSSNRAW-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 644605   

TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM644605(US11866450, Compound 17 | Preparation of 6,6-dimet...)
Affinity DataEC50:  2.00E+3nMAssay Description:Bath 1 Buffer consisted of 1 mM MgCl2, 160 mM NaCl, 4.5 mM KCl, 10 mM HEPES, 10 mM Glucose, 2 mM CaCl2).Chloride Free Buffer consisted of 1 mM Magnes...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2024
Entry Details
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