BDBM648199 US20240025922, Example 169::synthesis of compound (R)-2-(4-((6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl)amino)phenyl)tetrahydrothiophene 1,1-dioxide and (S)-2-(4-((6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yl)amino)phenyl)tetrahydrothiophene 1,1-dioxide

SMILES Cc1c2NCCOc2ncc1N1CCc2cnc(Nc3ccc(cc3)[C@H]3CCCS3(=O)=O)cc2C1

InChI Key InChIKey=MWVBZSICEHHHIL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 648199   

LigandPNGBDBM648199(US20240025922, Example 169 | synthesis of compound...)
Affinity DataIC50: 100nMAssay Description:A recombinant fusion protein consisting of full-length human HPK1 (MAP4K1) with an N-terminal Glutatione S-transferase (GST) tag was produced in inse...More data for this Ligand-Target Pair
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Date in BDB:
3/19/2024
Entry Details
US Patent