BDBM657025 2-(3-(5-Amino-6-(1-(methyl-d3)-1H-pyrazol-5-yl)pyrazin-2-yl)-4-methylphenyl)-3,3,3-trifluoropropane-1,2-diol::US11926616, Example 1a

SMILES [2H]C([2H])([2H])n1nccc1-c1nc(cnc1N)-c1cc(ccc1C)[C@@](O)(CO)C(F)(F)F

InChI Key InChIKey=ZXZHCVPLLUPOLK-BMSJAHLVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 657025   

LigandPNGBDBM657025(US11926616, Example 1a | 2-(3-(5-Amino-6-(1-(methy...)
Affinity DataIC50: 100nMAssay Description:PI3Kδ (p110δ/p85α) Recombinant Human Protein was purchased from Eurofins (St Charles, MO). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657025(US11926616, Example 1a | 2-(3-(5-Amino-6-(1-(methy...)
Affinity DataIC50: 100nMAssay Description:PI3Kγ (p110γ) Recombinant Human Protein was purchased from Life technology (Grand Island, NY). ATP, MgCl2, DTT, EDTA, MOPS and CHAPS were p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
US Patent

LigandPNGBDBM657025(US11926616, Example 1a | 2-(3-(5-Amino-6-(1-(methy...)
Affinity DataIC50: 500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent

LigandPNGBDBM657025(US11926616, Example 1a | 2-(3-(5-Amino-6-(1-(methy...)
Affinity DataIC50: 500nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2025
Entry Details
US Patent