BDBM657592 6,7-dimethoxy-2-methyl-N-[1-(4-{2-[(methylamino)methyl]phenyl}thiophen-2-yl)ethyl]quinazolin-4-amine::US20240083857, Example 271::US20240083857, Example 326::US20240083857, Example 327

SMILES CNCc1ccccc1-c1csc(c1)C(C)Nc1nc(C)nc2cc(OC)c(OC)cc12

InChI Key InChIKey=WEGLOYDTDILXDA-UHFFFAOYSA-N

Data  26 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 657592   

TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 1.32E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataKd:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGuanine nucleotide exchange factor DBS(Homo sapiens)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 61nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 2(Homo sapiens)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 60.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.56E+3nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 1.94E+3nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 1.38E+3nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 27.7nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 29.1nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 12.9nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 75.9nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM657592(US20240083857, Example 271 | US20240083857, Exampl...)
Affinity DataIC50: 72.6nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent