BDBM657643 N-[1-(5-{2-[(3-fluoroazetidin-1-yl)methyl]phenyl}thiophen-2-yl)ethyl]-6,7-dimethoxy-2-methylquinazolin-4-amine::US20240083857, Example 322
SMILES COc1cc2nc(C)nc(NC(C)c3ccc(s3)-c3ccccc3CN3CC(F)C3)c2cc1OC
InChI Key InChIKey=KYSIUGKAPVEMTL-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 657643
Affinity DataIC50: 408nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
Affinity DataIC50: 268nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair