BDBM657690 6,7-dimethoxy-N-{1-[5-(2-{[(2-methoxyethyl)amino]methyl}phenyl)thiophen-2-yl]ethyl}-2-methylquinazolin-4-amine::US20240083857, Example 369
SMILES COCCNCc1ccccc1-c1ccc(s1)C(C)Nc1nc(C)nc2cc(OC)c(OC)cc12
InChI Key InChIKey=VZMHUVYOYVZVIQ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 657690
Affinity DataIC50: 99.5nMAssay Description:The expression and purification of N-terminal GST-tagged human K-RasG120 and N-terminal His-tagged human SOS1 is described below. Concentrations of p...More data for this Ligand-Target Pair
Affinity DataIC50: 152nMAssay Description:Preparation of GST-tagged hK-RasGl2C loaded with fluorescent nucleotide was performed as follows: incubation of 11.5 μM hK-RasGl2C with 5-fold e...More data for this Ligand-Target Pair
Affinity DataIC50: 169nMAssay Description:This assay quantifies human SOS1-mediated loading of human K-RasG12C-GDP with a fluorescent GTP-analog. Detection of successful loading is achieved b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair