BDBM658250 6-[3-(5-chloro-2-methoxypyridine-3-sulfonamido)-2,6-difluorophenyl]-N-[4-[(dimethylamino)methyl]phenyl]imidazo[1,5-a]pyrazine-1-carboxamide ::US20240083897, Compound 181

SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(c1F)-c1cn2cnc(C(=O)Nc3ccc(CN(C)C)cc3)c2cn1

InChI Key InChIKey=RUHLRFZTXPWUDW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 658250   

TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658250(US20240083897, Compound 181 | 6-[3-(5-chloro-2-met...)
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
US Patent