BDBM660953 Synthesis of (1R,3S)-3-((1-((2-methylpyrimidin-5-yl)amino)isoquinolin-6-yl)oxy)cyclohexan-1-ol and (1 S,3R)-3-((1-((2-methylpyrimidin-5-yl)amino)isoquinolin-6-yl)oxy)cyclohexan-1-ol::US20240101531, Example 339::US20240101531, Example 357

SMILES Cc1ncc(Nc2nccc3cc(O[C@H]4CCC[C@@H](O)C4)ccc23)cn1

InChI Key InChIKey=RCNMKZMYQFTFOA-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 660953   

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660953(US20240101531, Example 339 | US20240101531, Exampl...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660953(US20240101531, Example 339 | US20240101531, Exampl...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent