BDBM660991 Synthesis of N-((1 S,3R)-3-((1-((2-chloropyrimidin-5-yl)amino)isoquinolin-6-yl)oxy)cyclohexyl)-2,2,2-trifluoroacetamide and N-((1 S,3R)-3-((1-((2-chloropyrimidin-5-yl)amino)isoquinolin-6-yl)oxy)cyclohexyl)acetamide::US20240101531, Example 377

SMILES FC(F)(F)C(=O)N[C@H]1CCC[C@H](C1)Oc1ccc2c(Nc3cnc(Cl)nc3)nccc2c1

InChI Key InChIKey=GJSZPAKMCPIHMX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 660991   

TargetPotassium voltage-gated channel subfamily KQT member 2/3 (Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM660991(Synthesis of N-((1 S,3R)-3-((1-((2-chloropyrimidin...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
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Date in BDB:
6/11/2024
Entry Details
US Patent