BDBM662985 Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2-yn-1-ylamino)quinazolin-2(1H)-one ::US20240109880, Compound 10::US20250059204, Compound 2

SMILES COc1cccc(OC)c1S(=O)(=O)Nc1noc2cc(Cn3cccn3)c3CCOc3c12

InChI Key InChIKey=BYICTVGRFYUHAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662985   

TargetHistone acetyltransferase KAT6A [507-778](Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM662985(Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2...)
Affinity DataIC50: 5nMAssay Description:Inhibition of KAT6A enzymatic activity by test compounds was determined using a radiometric 384-well format assay. A 10-point serial dilution of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
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TargetHistone acetyltransferase KAT6A(Human)
Aurigene Oncology

US Patent
LigandPNGBDBM662985(Synthesis of 7-chloro-1-(2-chlorophenyl)-4-(prop-2...)
Affinity DataIC50: 20nMAssay Description:TR-FRET is homogeneous proximity assay where Europium-labelled anti-acetyl lysine antibody binds to the acetylated substrate labelled with biotin whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2025
Entry Details
Go to US Patent