BDBM6650 1-benzyl-3-(7-hydroxynaphthalen-1-yl)urea::CHEMBL139989::Diarylurea deriv. 1e::N-Benzyl-N -(7-hydroxy-1-naphthyl)urea

SMILES Oc1ccc2cccc(NC(=O)NCc3ccccc3)c2c1

InChI Key InChIKey=NTZXOVWJUVTXIF-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 6650   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Banyu Tsukuba Research Institute

LigandPNGBDBM6650(CHEMBL139989 | N-Benzyl-N -(7-hydroxy-1-naphthyl)u...)
Affinity DataIC50: 4.10E+5nMT: 2°CAssay Description:In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2005
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM6650(CHEMBL139989 | N-Benzyl-N -(7-hydroxy-1-naphthyl)u...)
Affinity DataIC50: 45nMAssay Description:Functional antagonistic activity against human vanilloid receptor subtype 1 in HEK293 cell membranes was determined as inhibition of agonist-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM6650(CHEMBL139989 | N-Benzyl-N -(7-hydroxy-1-naphthyl)u...)
Affinity DataKi:  94nMAssay Description:Binding affinity towards cloned human vanilloid receptor subtype 1 in HEK293 cell membranes using [3H]RTX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed