BDBM665716 US20240116922, Example 18

SMILES CC(C)Oc1c(cn2cc(nc2n1)C34CC(C3)(OC4)C)C(=O)NC5=CC=CN(C5=O)C6CC6

InChI Key InChIKey=JJZLDWBCAMPSMG-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 665716   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Ma

US Patent
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 0.200nMAssay Description:The 2-hour 1 mM ATP Biochemical Assay employed a MesoScale Detection (MSD) format. The kinase reaction was based on the IRAK4 phosphorylation of a bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biogen Ma

US Patent
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 0.230nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 418nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 752nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 1.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 2.17E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Biogen Inc.

Curated by ChEMBL
LigandPNGBDBM665716(US20240116922, Example 18)
Affinity DataIC50: 2.75E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed