BDBM670747 2-cyano-N-[(3R)-1-[7-(ethylamino)-5-fluoro-3-methyl-2-oxo-indolin-3-yl]-3-piperidyl]-2-azaspiro[3.3]heptane-6-carboxamide::US20240140933, Example 37

SMILES CCNc1cc(F)cc2c1NC(=O)C2(C)N1CCC[C@@H](C1)NC(=O)C1CC2(C1)CN(C2)C#N

InChI Key InChIKey=QTMOOMDTXWZZBT-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670747   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Hoffmann-La Roche

US Patent

LigandBDBM670747(2-cyano-N-[(3R)-1-[7-(ethylamino)-5-fluoro-3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 86nMAssay Description:The inhibitory potency of compounds of PDHK1 activity was determined in an enzymatic assay. Pyruvate dehydrogenase complex (PDHc) is an enzyme that c...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2024
Entry Details
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