BDBM670897 (6R)-N-(4-cyano-1,1- dioxidotetrahydro-2H-thiopyran- 4-yl)-3-(5-fluoro-2-(2,2,2- trifluoroethoxy)pyridin-4-yl)-1- (3-hydroxy-3-methylbutan-2-yl)- 4,5,6,7-tetrahydro-1H-indazole-6- carboxamide (faster eluting with OD-H column, 12% EtOH/CO2)::US20240140938, Example 113a::US20240140938, Example 113b

SMILES CC(n1nc(c2CC[C@H](Cc12)C(=O)NC1(CCS(=O)(=O)CC1)C#N)-c1cc(OCC(F)(F)F)ncc1F)C(C)(C)O

InChI Key InChIKey=MUOIKSJXBZWFAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670897   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670897((6R)-N-(4-cyano-1,1- dioxidotetrahydro-2H-thiopyra...)
Affinity DataIC50: 27.8nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670897((6R)-N-(4-cyano-1,1- dioxidotetrahydro-2H-thiopyra...)
Affinity DataIC50: 70.3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent