BDBM674473 2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6-formamido) Acetic Acid::US11981669, Compound Link-121

SMILES OC(=O)CNC(=O)c1nc(Br)c2nc(Oc3ccccc3)ccc2c1O

InChI Key InChIKey=ZHQORCUIIRDXGE-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 674473   

TargetProlyl hydroxylase EGLN2(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 40.3nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetProlyl hydroxylase EGLN3(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 95.6nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetEgl nine homolog 1(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 353nMAssay Description:VHL/elongin B/elongin C were constructed, expressed and purified, and VHL was labeled. PHD1, PHD2 and PHD3 were constructed, expressed and purified. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:The compounds of the present disclosure were subjected to the CYP450 enzyme inhibition assay. The experimental results showed that the compounds of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:The compounds of the present disclosure were subjected to the CYP450 enzyme inhibition assay. The experimental results showed that the compounds of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:The compounds of the present disclosure were subjected to the CYP450 enzyme inhibition assay. The experimental results showed that the compounds of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:The compounds of the present disclosure were subjected to the CYP450 enzyme inhibition assay. The experimental results showed that the compounds of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang)

US Patent
LigandPNGBDBM674473(2-(2-phenoxy-5-hydroxy-8-bromo-1,7-naphthyridine-6...)
Affinity DataIC50: 5.00E+4nMAssay Description:The compounds of the present disclosure were subjected to the CYP450 enzyme inhibition assay. The experimental results showed that the compounds of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent