BDBM678077 N-(1-cyclobutyl- 1H-pyrazol-4-yl)- 2-(5,6-dihydro- 4H-pyrrolo[1,2- b]pyrazol-3-yl)- 1,3-thiazole-4- carboxamide::US20240174679, Example 9-3

SMILES O=C(Nc1cnn(c1)C1CCC1)c1csc(n1)-c1cnn2CCCc12

InChI Key InChIKey=UBSXFNMLAADLQM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678077   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678077(US20240174679, Example 9-3 | N-(1-cyclobutyl- 1H-p...)
Affinity DataIC50: 9.77nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent