BDBM678187 US20240174690, Example II-19

SMILES CCCc1c(noc1[C@@]1(C)CCCc2sc(N)c(C#N)c12)-c1nc(O[C@@H](C)[C@@H]2CCCN2C)cc(n1)-n1ccc(n1)C(=O)N1CCCC1

InChI Key InChIKey=XZCGBNGXGZJFCN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 678187   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678187(US20240174690, Example II-19)
Affinity DataIC50: 1nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678187(US20240174690, Example II-19)
Affinity DataIC50: 1nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

TargetGTPase KRas [G13D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM678187(US20240174690, Example II-19)
Affinity DataIC50: 9nMAssay Description:These assays measure the inhibitory effect of compounds on KRAS mutant protein-protein interactions using the Alpha Screen technology by Perkin Elmer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent