BDBM683752 4-(6-chloro-4-{1,4- diazabicyclo[3.2.2]nonan- 4-yl}-8-fluoro-2-{[(2S)- 1-methylpyrrolidin-2- yl]methoxy}quinazolin-7- yl)naphthalen-2-ol::US20240217982, Example 1-2

SMILES CN1CCC[C@H]1COc1nc(N2CCN3CCC2CC3)c2cc(Cl)c(c(F)c2n1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=YDOBANPGJKCZPH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683752   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683752(US20240217982, Example 1-2 | 4-(6-chloro-4-{1,4- d...)
Affinity DataIC50: 1.37E+4nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent