BDBM684570 US12030897, Example 21::US12030897, Example 22::US12030897, Example 23::US12030897, Example 24

SMILES Cc1cc(Nc2ncnn3ccc(CN4CC[C@H](N)[C@@H](F)C4)c23)ccc1Oc1ccn2ncnc2c1

InChI Key InChIKey=ALZWUAVTIXIKIX-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 684570   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 2nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 3nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 4nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 6nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 41nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 61nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 109nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 139nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 306nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 438nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 909nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Medshine Discovery

US Patent
LigandPNGBDBM684570(US12030897, Example 21 | US12030897, Example 23 | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:The object of this test is to detect the in vitro inhibitory activity of the compound against HER1 (ErbB1), HER2 (ErbB2) and HER4 (ErbB4). The enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent