BDBM684823 3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluoromethyl)phenyl)-4-fluoro-2- (((2R,7aS)-2-fluorotetrahydro-1H- pyrrolizin-7a(5H)-yl)methoxy)-8,9- dihydro-10H-7-oxa-1,3,6,10- tetraazacyclohepta[de]naphthalen-10- yl)ethyl)pyridin-2-amine::US20240228512, Example 5::US20260137699, Example 5
SMILES C[C@@H](N1CCOc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23)-c1cc(N)c(F)c(C)c1C(F)(F)F)c1cccnc1N
InChI Key InChIKey=PPBGAGVPXQANIX-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 684823
Affinity DataIC50: 0.0450nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0450nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0530nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0530nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair