BDBM684858 US20240228512, Example 626::US20260137699, Example 626

SMILES C[C@@H](N1CCOc2nc(c(Cl)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc1c23)-c1cc(N)nc(C)c1C(F)(F)F)c1cccnc1N

InChI Key InChIKey=XNUGLARAPXNJKT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 684858   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684858BDBM684858(US20240228512, Example 626 | US20260137699, Exampl...)
Affinity DataIC50: 0.160nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684858BDBM684858(US20240228512, Example 626 | US20260137699, Exampl...)
Affinity DataIC50: 0.160nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684858BDBM684858(US20240228512, Example 626 | US20260137699, Exampl...)
Affinity DataIC50: 0.670nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684858BDBM684858(US20240228512, Example 626 | US20260137699, Exampl...)
Affinity DataIC50: 0.670nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent