BDBM685093 2-((1R,4R,7R)- 7-amino-2-aza- bicyclo[2.2.1] heptan-2-yl)-5- (3-chloro-4- fluoro-2-methyl- 2H-indazol-5- yl)-3-methyl- 3,7-dihydro-4H- pyrrolo[2,3-d] pyrimidin-4-one::US12037345, Example 174

SMILES Cn1nc2ccc(-c3c[nH]c4nc(N5C[C@H]6CC[C@@H]5[C@@H]6N)n(C)c(=O)c34)c(F)c2c1Cl

InChI Key InChIKey=ZQYMDBORVHQUEX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685093   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM685093(US12037345, Example 174 | 2-((1R,4R,7R)- 7-amino-2...)
Affinity DataIC50: 3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
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Date in BDB:
10/24/2024
Entry Details
US Patent