BDBM685208 4-(4-((1S,4S)-2,5-diazabicyclo[2.2.2]octan-2-yl)-2-((1- ((dimethylamino)methyl)cyclopropyl)methoxy)-6,8- difluoroquinazolin-7-yl)naphthalen-2-ol::US20240239788, Example 7

SMILES CN(C)CC1(COc2nc(N3C[C@@H]4CC[C@H]3CN4)c3cc(F)c(c(F)c3n2)-c2cc(O)cc3ccccc23)CC1

InChI Key InChIKey=NQQCYNMKOWECEC-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685208   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM685208(US20240239788, Example 7 | 4-(4-((1S,4S)-2,5-diaza...)Copy SMILESCopy InChI

Affinity DataIC50: 2.99E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2024
Entry Details
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