BDBM685218 (1S,5S,6R)-3-(6,8-difluoro- 7-(3-hydroxynaphthalen-1- yl)-2-((1- (morpholinomethyl)cyclo- propyl)methoxy)quinazolin- 4-yl)-3,8- diazabicyclo[3.2.1]octan-6- ol::US20240239788, Example 17

SMILES OC1CC2CN(CC1N2)c1nc(OCC2(CN3CCOCC3)CC2)nc2c(F)c(c(F)cc12)-c1cc(O)cc2ccccc12

InChI Key

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685218   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM685218(US20240239788, Example 17 | (1S,5S,6R)-3-(6,8-difl...)Copy SMILES

Affinity DataIC50: 3.26E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2024
Entry Details
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