BDBM685225 4-(2-((1- ((dimethylamino)meth- yl)cyclopropyl)meth- oxy)-6,8-difluoro-4-(6- methoxy-3,8-di- azabicyclo[3.2.1]octan- 3-yl)quinazolin-7- yl)naphthalen-2-olR,R,::US20240239788, Example 24::US20240239788, Example 26

SMILES COC1CC2CN(CC1N2)c1nc(OCC2(CN(C)C)CC2)nc2c(F)c(c(Cl)cc12)-c1cc(O)cc2ccccc12

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 685225   

LigandPNGBDBM685225(4-(2-((1- ((dimethylamino)meth- yl)cyclopropyl)met...)
Affinity DataIC50: 1.08E+4nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent

LigandPNGBDBM685225(4-(2-((1- ((dimethylamino)meth- yl)cyclopropyl)met...)
Affinity DataIC50: 1.18E+4nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent