BDBM685229 4-(6-chloro-2-((1- ((dimethylamino)meth- yl)cyclopropyl)meth- oxy)-8-fluoro-4- ((1S,4S,6R)-6- methyl-2,5- diazabicyclo [2.2.2]octan-2- yl)quinazolin- 7-yl)naphthalen-2-ol::US20240239788, Example 31

SMILES C[C@H]1N[C@H]2CC[C@@H]1N(C2)c1nc(OCC2(CN(C)C)CC2)nc2c(F)c(c(Cl)cc12)-c1cccc2cc(O)ccc12

InChI Key InChIKey=ZXDRKWXHGAFFJZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685229   

LigandPNGBDBM685229(US20240239788, Example 31 | 4-(6-chloro-2-((1- ((d...)
Affinity DataIC50: 1.79E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent