BDBM685341 8-(4-(3,8-diazabicyclo[3.2.1]octan-3- yl)-6-chloro-8-fluoro-2-((1- (morpholinomethyl)cyclopropyl)methoxy) quinazolin-7-yl)-5-fluoroquinolin-2- amine::US20240239788, Example 52

SMILES Nc1ccc2c(F)ccc(-c3c(Cl)cc4c(nc(OCC5(CN6CCOCC6)CC5)nc4c3F)N3CC4CCC(C3)N4)c2n1

InChI Key InChIKey=BKNOCEFTZNMWTD-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685341   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM685341(US20240239788, Example 52 | 8-(4-(3,8-diazabicyclo...)Copy SMILESCopy InChI

Affinity DataIC50: 3.83E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2024
Entry Details
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