BDBM685346 US20240239788, Example 61

SMILES Nc1nc2c(ccc(F)c2s1)-c1c(F)cc2c(nc(OCC3(CN4CC[C@@H](F)C4)CC3)nc2c1F)N1CC2CCC(C1)N2

InChI Key InChIKey=MAZNYZKVVQPGJC-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685346   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM685346(US20240239788, Example 61)Copy SMILESCopy InChI

Affinity DataIC50: 3.35E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2024
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL