BDBM685352 4-(4-(3,8-diazabicyclo[3.2.1]octan- 3-yl)-6-chloro-8-fluoro-2-((1- (morpholinomethyl)cyclopropyl) methoxy)quinazolin-7-yl)-7- fluorobenzo[d]thiazol-2-amine::US20240239788, Example 62

SMILES Nc1nc2c(ccc(F)c2s1)-c1c(Cl)cc2c(nc(OCC3(CN4CCOCC4)CC3)nc2c1F)N1CC2CCC(C1)N2

InChI Key InChIKey=HDAMXKVFBHKUOD-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685352   

TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent

LigandBDBM685352(US20240239788, Example 62 | 4-(4-(3,8-diazabicyclo...)Copy SMILESCopy InChI

Affinity DataIC50: 334nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2024
Entry Details
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