BDBM685405 1-((1R)-1-(((7-(5,6-dimethyl-1H-indazol- 4-yl)-6,8-difluoro-4-((1S,5R)-1-methyl-3,8- diazabicyclo[3.2.1]octan-3-yl)quinazolin-2- yl)oxy)methyl)-2,2-difluorocyclopropyl)- N,N-dimethylmethanamine::US20240239788, Example 82
SMILES CN(C)C[C@@]1(COc2nc(N3C[C@H]4CC[C@](C)(C3)N4)c3cc(F)c(c(F)c3n2)-c2c(C)c(C)cc3[nH]ncc23)CC1(F)F
InChI Key InChIKey=IBONVUIPNSJRNP-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 685405
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 1.48E+4nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair