BDBM685451 8-(6-chloro-2-(((R)-1-((dimethyalmino)methyl)- 2,2-difluorocyclopropyl)methoxy)-8-fluoro-4- ((1S,5R)-1-methyl-3,8-diazabicyclo[3.2.1]octan- 3-yl)quinazolin-7-yl)-5,7-difluoroquinolin-2- amine::US20240239788, Example 92b
SMILES CN(C)C[C@@]1(COc2nc(N3C[C@H]4CC[C@](C)(C3)N4)c3cc(Cl)c(c(F)c3n2)-c2c(F)cc(F)c3ccc(N)nc23)CC1(F)F
InChI Key InChIKey=BQEUBTSCXYWBTR-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 685451
TargetRAF proto-oncogene serine/threonine-protein kinase [50-132]/GTPase KRas [G12D](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 9.21E+3nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair