BDBM685461 4-(6,8-difluoro-2-((1-(((R)-3- fluoropyrrolidin-1- yl)methyl)cyclopropyl)methoxy)-4- ((1S,5R)-1-methyl-3,8- diazabicyclo[3.2.1]octan-3-yl)quinazolin- 7-yl)-5-ethynylnaphthalen-2-ol::US20240239788, Example 103a

SMILES C[C@@]12CC[C@H](CN(C1)c1nc(OCC3(CN4CC[C@@H](F)C4)CC3)nc3c(F)c(c(F)cc13)-c1cc(O)cc3cccc(C#C)c13)N2

InChI Key InChIKey=WWRNTXKWSLTMFN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 685461   

LigandPNGBDBM685461(US20240239788, Example 103a | 4-(6,8-difluoro-2-((...)
Affinity DataIC50: 26.2nMAssay Description:The RAF-Ras binding domain (RBD) protein interaction assay utilizes recombinant biotinylated KRAS protein containing a G12D mutation (SEQ ID NO: 1) a...More data for this Ligand-Target Pair
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Date in BDB:
10/30/2024
Entry Details
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