BDBM687756 Synthesis of N-(1-(3-methoxyphenyl)cyclopropyl)-1-methyl-6-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide ::US20240246972, Compound 3

SMILES COc1cccc(c1)C1(CC1)NC(=O)c1cc2ccc(nc2n1C)-c1cn[nH]c1

InChI Key InChIKey=PMXKUMCLYSFPJB-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 687756   

TargetRho-associated protein kinase 2(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 0.800nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 21.2nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 396nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataIC50: 830nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataKd:  8.90E+4nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent