BDBM687935 2-{3-[(1R)-1-{[6-(1-acetyl-4-oxo-1,4lambda5-azaphosphinan-4-yl)-2-methylpyrido[3,4-d]pyrimidin-4-yl]amino}ethyl]-2-fluorophenyl}-2,2-difluoroacetamide::US20240247015, Example 46

SMILES C[C@@H](Nc1nc(C)nc2cnc(cc12)P1(=O)CCN(CC1)C(C)=O)c1cccc(c1F)C(F)(F)C(N)=O

InChI Key InChIKey=QWVGLVYZODSIMN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 687935   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM687935(US20240247015, Example 46 | 2-{3-[(1R)-1-{[6-(1-ac...)
Affinity DataIC50: 6.10nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
11/7/2024
Entry Details
US Patent