BDBM688409 US20240190824, Compound 8::tert-butyl N-[4-chloro-3-[[5-[2-(4- fluorophenyl)ethynyl]-3-methyl-2- pyridyl]carbamoyl]phenyl]carbamate

SMILES Cc1cc(cnc1NC(=O)c1cc(NC(=O)OC(C)(C)C)ccc1Cl)C#Cc1ccc(F)cc1

InChI Key InChIKey=DFSZNGQSGYXXNF-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 688409   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 15nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 67nMAssay Description:Inhibition of human TREK-1 channel by manual patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium channel subfamily K member 2(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human TREK-1 channel expressed in CHO cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataIC50: 260nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetAdenosine receptor A3(Human)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataKi:  480nMAssay Description:Inhibition of human adenosine A3 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Rat)
Ono Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688409BDBM688409(US20240190824, Compound 8 | tert-butyl N-[4-chloro...)
Affinity DataKi:  650nMAssay Description:Inhibition of rat Nav1.5 channel assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed