BDBM694225 (R)-3-((7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl)-N-methyl-1,2,3,4,4a,5-hexahydro-7H-pyrazino[2,1-c]pyrido[3,2-e][1,4]oxazepine-9-carboxamide 8::US20240287094, Example 8

SMILES CCc1cc2ncc(CN3CCN4[C@H](C3)COCc3nc(ccc43)C(=O)NC)cc2[nH]c1=O

InChI Key InChIKey=KDIVJSFAVWBRRL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 694225   

TargetPoly [ADP-ribose] polymerase 1(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM694225(US20240287094, Example 8 | (R)-3-((7-Ethyl-6-oxo-5...)
Affinity DataIC50: 19nMAssay Description:In vitro binding activities for PARP1 and PARP2 were tested by the following method.I. Materials and instruments1. PARP1 recombinant protein (Sino Bi...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Jiangsu Hengrui Pharmaceuticals

US Patent
LigandPNGBDBM694225(US20240287094, Example 8 | (R)-3-((7-Ethyl-6-oxo-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro binding activities for PARP1 and PARP2 were tested by the following method.I. Materials and instruments1. PARP1 recombinant protein (Sino Bi...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent