BDBM694484 US20240293412, Compound TABLE2.37

SMILES FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1

InChI Key InChIKey=PNEQDEPNUMZDMO-UHFFFAOYSA-N

Data  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694484   

TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694484(US20240293412, Compound TABLE2.37)
Affinity DataEC50:  58nMAssay Description:All FP measurements were performed at room temperature in PBS buffer containing 0.01% Triton-X 100 and 1% DMSO in black 384-well plates. Measurements...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694484(US20240293412, Compound TABLE2.37)
Affinity DataEC50:  58nMAssay Description:Positive allosteric modulation of C-terminal His6-tagged wild type human NAMPT using NAM and PRPP as substrates measured for 1 hr by NMNAT1-coupled e...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694484(US20240293412, Compound TABLE2.37)
Affinity DataKd:  85nMAssay Description:Displacement of FP-probe ZN-2-102 from C-terminal His6-tagged wild type human NAMPT rear channel assessed as dissociation constant by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
University of Illinois

US Patent
LigandPNGBDBM694484(US20240293412, Compound TABLE2.37)
Affinity DataEC50:  85nMAssay Description:Positive allosteric modulation of NAMPT in human THP-1 cells assessed as increase in cellular NAD+ level incubated for 24 hrs by NAD/NADH-Glo assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed