BDBM694739 (7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-methyl-13-oxa-18-thia-2,5,8-triazatetracyclo[8.8.0.02,6.011,17]octadeca-1(10),3,5,8,11::US20240294543, Example 66

SMILES C[C@@H]1N=C(c2c3COCCCc3sc2-n2cc(nc12)C(=O)NCCO)c1c(F)cccc1F

InChI Key InChIKey=GHHDUOPSIZMGFL-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 694739   

LigandPNGBDBM694739((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-m...)
Affinity DataKi:  2.94nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
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Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694739((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-m...)
Affinity DataKi:  14.7nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

LigandPNGBDBM694739((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-m...)
Affinity DataKi:  14.7nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
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LigandPNGBDBM694739((7S)-9-(2,6-difluorophenyl)-N-(2-hydroxyethyl)-7-m...)
Affinity DataKi:  2.51E+3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 uL (96-well plates) which contained 100 uL of cell membranes, [3H]Flumazenil ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent