BDBM6967 2-substituted quinazoline 17::ethyl 4-(tert-butylamino)quinazoline-2-carboxylate

SMILES CCOC(=O)c1nc(NC(C)(C)C)c2ccccc2n1

InChI Key InChIKey=FTQWNIXCYZUMFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6967   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6967(ethyl 4-(tert-butylamino)quinazoline-2-carboxylate...)
Affinity DataIC50: 5.80E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6967(ethyl 4-(tert-butylamino)quinazoline-2-carboxylate...)
Affinity DataIC50: 1.68E+5nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed