BDBM6978 4-substituted quinazoline 28::N-[(3-fluorophenyl)methyl]-2-(trifluoromethyl)quinazolin-4-amine

SMILES Fc1cccc(CNc2nc(nc3ccccc23)C(F)(F)F)c1

InChI Key InChIKey=HKQARPZRSRQTEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6978   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6978(N-[(3-fluorophenyl)methyl]-2-(trifluoromethyl)quin...)
Affinity DataIC50: 1.56E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6978(N-[(3-fluorophenyl)methyl]-2-(trifluoromethyl)quin...)
Affinity DataIC50: 3.90E+4nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed