BDBM6989 6-substituted quinazoline 39::N-tert-butyl-6-(furan-2-yl)-2-(trifluoromethyl)quinazolin-4-amine

SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)-c1ccco1)C(F)(F)F

InChI Key InChIKey=VNZAKQOQHSANKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6989   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6989(N-tert-butyl-6-(furan-2-yl)-2-(trifluoromethyl)qui...)
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6989(N-tert-butyl-6-(furan-2-yl)-2-(trifluoromethyl)qui...)
Affinity DataIC50: 3.00E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed