BDBM6991 6-substituted quinazoline 41::N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)quinazolin-4-amine

SMILES CC(C)(C)Nc1nc(nc2ccc(cc12)-c1cccnc1)C(F)(F)F

InChI Key InChIKey=AUEDZAHHSVPOOC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6991   

TargetCyclin-dependent kinase 2(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 1.20E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Dupont Pharmaceuticals

LigandPNGBDBM6991(N-tert-butyl-6-(pyridin-3-yl)-2-(trifluoromethyl)q...)
Affinity DataIC50: 8.30E+3nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2005
Entry Details Article
PubMed