BDBM701468 US20240352000, Example 14

SMILES CCC(=O)N1CCc2cccc(Nc3nc(Nc4ccc(N5CCC(N6CCN(C)CC6)CC5)cc4OC)ncc3Cl)c21

InChI Key InChIKey=AYMPIGIVTVNATJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 701468   

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701468(US20240352000, Example 14)
Affinity DataIC50: 91nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
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TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701468(US20240352000, Example 14)
Affinity DataIC50: 50nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-763,'FHEA',764-1210](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701468(US20240352000, Example 14)
Affinity DataIC50: 100nMAssay Description:An experiment to measure the activity of the compounds of the present invention against EGFR mutant enzymes was performed as follows using the HTRF s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM701468(US20240352000, Example 14)
Affinity DataIC50: 100nMAssay Description:An experiment to measure the activity of the compounds of the present invention against HER mutant enzymes was performed as follows using the HTRF sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
Go to US Patent