BDBM704733 3-Hydroxy-5- (4-cyclohexyl-3- phenylisoxazol-5-yl) picolinoyl glycine::US20240376089, Compound I-32

SMILES O=C(O)CNC(=O)c1ncc(-c2onc(-c3ccccc3)c2C2CCCCC2)cc1O

InChI Key InChIKey=CKWOHSRYJAVKKZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 704733   

TargetEgl nine homolog 1/Hypoxia-inducible factor 1-alpha [788-822](Human)
China Pharmaceutical University

US Patent
LigandPNGBDBM704733(3-Hydroxy-5- (4-cyclohexyl-3- phenylisoxazol-5-yl)...)
Affinity DataIC50: 998nMAssay Description:The ability of the compounds to compete with a fluorophore-labeled HIF-la peptide fragment (FITC-HIF-1α 788-822) for binding to the PHD2 protein was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent