BDBM70816 US9546164, 4::US9694002, 6

SMILES Fc1ccc(CN2CCC[C@H](C2)Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)c(Cl)c1

InChI Key InChIKey=KRNHAUPCKRIYSK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 70816   

LigandPNGBDBM70816(US9694002, 6 | US9546164, 4)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70816(US9694002, 6 | US9546164, 4)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70816(US9694002, 6 | US9546164, 4)
Affinity DataIC50: 33nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM70816(US9694002, 6 | US9546164, 4)
Affinity DataIC50: 6.60E+3nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
Go to US Patent